EMS Obesity Research Journal

EMS Obesity Research Journal (EMSORJ) is a peer-reviewed, Open Access journal and aims to publish the absolute and reliable source of the discoveries and current developments in the mode of original research manuscripts, review manuscripts, and clinical studies in all areas of Obesity Research. The journal provides a medium to researchers, professionals, scholars, academicians and industrial aspirants to publish and disseminate their scientific research endeavor.

EMSORJ encourages submission of manuscripts related to (but not limited to) Childhood Obesity, Adolescence Obesity, Morbid Obesity, Obesity & Diabetes, Overweight, Obesity & Weight Loss, etc.

Weight regain is an increasingly common problem following weight loss through both dietary intervention and bariatric surgery, with no solution in sight. Furthermore, the issue of whether or not a weight set point exists remains unresolved, despite several competing theories. Additionally, research into the potential regulatory hormonal mechanisms shows no consistent results and no indicators of a therapeutic regimen. A fresh approach is required. There are several possible areas which warrant investigation but have not been studied at all, such as whether weight regain might be prevented or slowed if individuals were no longer in insulin or leptin resistance or if they were in a state of fairly continuous ketosis. There are a few mechanism studies which show promise for further investigation, as well as providing a target for therapeutic intervention: upregulation of regulatory T cells to counter a potential pro-inflammatory 'obesity memory' of T helper cells; improving the composition and diversity of the microbiome; flavonoid supplementation; inhibition of angiotensin converting enzyme and/or sodium reduction and provision of an aryl hydrocarbon receptor ligand. Studies of the therapeutic substances shown to be beneficial in reducing weight regain (dexamethasone, salicylates and the flavonoids apigenin and naringenin) show that they all function through several of these potential mechanisms, suggesting that all might warrant further investigation.